- HD 1080
- Runtime: 76m.
- Status: Released
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- Languages: en
- Country: United States of America
- Director: Mike Strain Jr.
- Stars: Brian Southwick, Ronnie Sortor, Daniel Skinner, Lily Strain, Tammi Strain
- keywords: shot on video, genetic mutation, science fiction, horror, action, experiments
- Production_studio: Oaktree Studios, Studio 2060
- Slogan: Science and mother nature don't mix!
- The Vile 21 is featured in the top rankings of 1998
- #10 in Top Action Movies of 1998
- #3 in Top Horror Movies of 1998
When Dr. Walter Hall creates a drug that turns men into rampaging creatures, the government forces him to continue his unorthodox experiments. Coerced by the authorities, he injects the serum into an unsuspecting derelict and unleashes an unspeakable terror upon the community-a monster-part man - part reptile...part alien. Now twenty years later, the creature has resurfaced and Dr. Hall must literally put the devil to rest by reopening the old experiment by once again confronting the evil he knows as...VILE 21.