- HD 1080
- Runtime: 80m.
- Status: Released
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- Languages: en
- Country: United States of America
- Director: John Bacchus
- Stars: Darian Caine, Heidi Christine, Victoria Vega, Debbie Rochon, A.J. Khan
- Production_studio: Seduction Cinema
- Slogan: Her "Man-Made" Lust Cannot be Satisfied!
- The Mistress Frankenstein is featured in the top rankings of 2000
- #31 in Top Fantasy Movies of 2000
- #37 in Top Horror Movies of 2000
Dr. Victor Frankenstein neglects the sexual needs of his frigid and frustrated wife Helena. After Helena gets killed in a horse riding accident, Victor decides to bring her back to life. However, Victor's inept assistant Igor accidentally damages Helena's brain and replaces it with a lesbian's brain, so Helena is now a crazed, aggressive, and predatory vixen with a raging insatiable libido.