- HD 1080
- Runtime: 77m.
- Status: Released
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- Languages: en
- Country: United Kingdom
- Director: Graham Cutts
- Stars: Arthur Wontner, Isla Bevan, Ian Hunter, Graham Soutten, Herbert Lomas
- keywords: sherlock holmes
- Production_studio: Associated Talking Pictures (ATP)
- The The Sign of Four: Sherlock Holmes' Greatest Case is featured in the top rankings of 1932
- #57 in Top Romance Movies of 1932
- #10 in Top Action Movies of 1932
- #25 in Top Crime Movies of 1932
- #8 in Top Thriller Movies of 1932
- #13 in Top Mystery Movies of 1932
A young woman turns to Holmes for protection when she's menaced by an escaped killer seeking missing treasure. However, when the woman is kidnapped, Holmes and Watson must penetrate the city's criminal underworld to find her.