- HD 1080
- Runtime: 25m.
- Status: Canceled
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- Languages: en
- Country: United States of America
- Stars: Christina Applegate, Jennifer Esposito, Kevin Dunn, Melissa McCarthy, Tim Russ
- keywords: memory loss, good deed
- Production_studio: Brillstein Entertainment Partners, ABC Studios, Donald Todd Productions
- Slogan: She's been a bad, bad girl... Good thing she can't remember.
- Seasons: 2
- Episodes: 35
- First air date: 2007-10-15
- Last air date: 2009-07-23
- The Samantha Who? is featured in the top rankings of 2007
- #33 in Top Comedy Series of 2007
Samantha Newly has been a bad, bad girl. But thanks to an 8-day coma, she can't remember a thing. Fortunately her best friend Andrea is by her side with a cocktail and the 4-1-1 on every dirty deed. But the more Sam pieces together her past, the less she likes her old self. Maybe this is a chance to start over and do it all again.